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Skin aging includes chronological aging and photoaging. The speed of skin aging is influenced by genetic, environmental and hormonal factors. Reasonable topical application of estrogens has proved to be a safe method for delaying skin aging. It has been evidenced that phytoestrogens, which generally exist in plants in the natural world, can promote the proliferation of epidermis as well as synthesis of collagen and hyaluronic acid, so as to prevent chronological aging and photoaging of skin. The effect of selective estrogen receptor modulators (SERMs) varies with the difference of tissues, and they may act as estrogen receptor agonists or antagonists. Some SERMs have potential anti-aging effect.

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