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RNA interference, a phenomenon of gene silencing mediated by double-stranded RNA, is a simple and effective method for blocking specific gene expression in mammalian cells. Oncolytic viruses are a kind of vectors that replicate specifically in tumor cells. With oncolytic viruses, small interference RNA could be delivered to target tumor cells, and the effects of oncogene silencing are also enhanced with the replication of viruses. Therefore, RNAi model mediated by oncolytic viruses opens up a new way for the gene therapy of tumors.

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