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Hypopigmented disorders are common in dermatology. They can arouse a major esthetic concern. Although the pathogenesis, histopathology and treatment vary among several hypopigmented disorders, such as vitiligo, nevus depigmentosus and progressive macular hypomelanosis, all of them are characterized by hypopigmented maculae. Hence, it is difficult to differentiate these diseases. This article reviews the progress in latest researches on pathomechanism, clinical manifestations, histopathology and treatments of several depigmented disorders, which may benefit the understanding of depigmented disorders and facilitate their clinical diagnosis and treatment.